RespirAid - Horse Respiratory Supplement
- Supports a healthy respiratory system
- Aids the capillary blood vessels surrounding the lungs
- Aids the management of respiratory problems such as cough, nasal discharge, and breathing problems
- Results in as little as 7 days
- 4.4lb (2kg) tub gives approximately 7-week supply
Research shows that supplementing horses’ diets with anti-oxidants (such as Vitamin C, Vitamin E, and selenium) aids the respiratory system, the blood vessels surrounding the lungs, and provides valuable nutritional support to help maintain respiratory tissue integrity. In a recent study of 37 horses, feeding RespirAid showed positive benefits in just 7 days (including decreased cough, nasal discharge, respiratory rate, and respiratory effort), and in another trial was shown to significantly increase plasma Vitamin C and Vitamin E in both moderate and aged horses. RespirAid also contains key minerals – zinc, copper – that aid in developing resilient tissues and repair of damaged tissues, and manganese, which acts as an anti-oxidant and has been shown to have positive effects when used for human COPD patients. Finally, RespirAid provide MSM for its anti-inflammatory capacity, as inflammation of the airways is a common cause of respiratory symptoms.
Respiratory stress is common for today's horses. Environmental factors such as stabling conditions, bedding, quality of ventilation, stress, travelling, mixing with other horses, allergens, pollution, dust, and fungi can accumulate in and irritate the sensitive lining of the lungs and respiratory tract. Further, some sports have high occurrence of leading to respiratory damage, due to the nature of the equine respiratory tract.
RespirAid should be fed on a daily basis to help support a healthy respiratory system, especially for horses at risk due to their sport or environment (chronic allergens, dust, pollution, mold, etc.). It is also ideal for horses and ponies that are stabled for long periods of time or have restricted turnout, those exposed to stressful situations (i.e. travelling, competition, change of barn), during changes in hay and feed, or for horses with seasonal allergies.
Instructions for Use & Feeding Guide:
Use the 25ml (21g) scoop provided.
For horses requiring extra respiratory support, higher doses can be given for 10 days. If after 10 days respiratory symptoms are improved, reduce to a maintenance dose.
Therapeutic Level Level 25ml (21.25g) scoops per day for 10 days
Pony - approximately 550lbs 3
Horse - approximately 1100lbs 4
Large Horse - over 1650lbs 5
Maintenance Level 25ml (21.25g) scoops per day
Pony - approximately 550lbs 1.5
Horse - approximately 1100lbs 2
Large Horse - over 1650lbs 2.5
-Introduce slowly, mix thoroughly with feed, and split between meals where possible.
-Monitor feeding other supplements containing selenium.
-Do not exceed the recommended intake.
Ingredients & Composition:
One of our core values is transparency. That’s why we list all the active ingredients per daily feeding rate so you know exactly what your horse is getting.
Active Ingredient Level:
Per 1100lb therapeutic daily dose (4 x 25ml) 85g RespirAid delivers: Vitamin C 10g; Vitamin E 4000IU; MSM 20g; Copper 100mg; Zinc 400mg; Manganese 400mg; Selenium 1mg.
Methyl sulphonyl methane; Ascorbyl monophosphate; Rice flour.
Protein 4.2%; Oils & Fats 22.5%; Ash 43.4%.
Additives (per kg):
Vitamin E (E3a700) all-rac-alpha-tocopheryl acetate (47 KIU/kg); Organic Selenium (derived from Saccharomyces cerevisae CNCM I-3060 – selenium inactivated yeast; E3b8.10) (12 mg/kg); Zinc (E6) from zinc chelate of amino acid (methionine) (4.71 g/kg); Copper (E4) from copper chelate of amino acid hydrate (1.18 g/kg); Manganese (E5) from chelate of amino acid hydrate (4.71 g/kg).
Research (affect on plasma Vitamins C and E; adult and aged horses):
QUESTION: Does Feeding an Oral Antioxidant Supplement Increase Plasma Vitamin C & E Concentrations in Adult and Aged Horses?
- Vitamins C and E are important antioxidants in lung fluid and lung tissue1. Inflammation, caused by allergy (e.g. equine asthma) or infection (e.g. virus or bacteria) causes reduction in antioxidants which allows inflammation to persist2,3.
- Supplementation with oral antioxidants has previously been shown to reduce airway inflammation and associated clinical signs in horses4,5.
Aim of Study
To determine the ability of an oral antioxidant supplement (RespirAid, Science Supplements) to raise plasma vitamin C and E concentrations in horses. As older horses may experience higher levels of oxidative stress and have a higher requirement for antioxidant vitamins, both adult and aged groups of horses were studied.
Placebo-controlled = some horses received the active supplement and some received a supplement with no active ingredients (placebo). Use of a placebo helps reduce bias (seeing a false positive result) and allows for the fact that an improvement might be observed from horses spontaneously improving.
Randomised = which horses were given placebo was pre-determined by a random system rather than a person deciding at the time of seeing a horse. This removes bias in the results caused by selecting only certain horses to have a particular treatment.
Blind = researchers did not know which horses received the active supplement and or placebo supplement. Blinding removes bias caused by people wanting to see a positive effect with the active supplement.
Twenty aged (minimum of 20 years old) horses and 20 adult (5-12 years old) horses were studied. Ten aged and 10 adult horses were fed RespirAid at the recommended rate for 6 weeks. The remaining 10 aged and 10 adult horses were fed a placebo for 6 weeks. Blood samples for analysis of plasma Vitamin C and E concentration were collected every 2 weeks.
- Plasma Vitamin C (Figure 1a) and Vitamin E (Figure 1b) concentrations were significantly increased after 2 weeks in both the aged and adult groups of horses fed the antioxidant supplement RespirAid, but were unchanged in the placebo fed group.
- In the horses given the antioxidant supplement, there was no significant difference in plasma Vitamin C & E concentrations between aged and adult horses after supplementation, indicating that aged horses are comparable with adult horses in their ability to absorb antioxidants from the diet.
Figure 1: Mean (+ standard deviation) plasma Vitamin C (a) and Vitamin E (b) concentrations in adult and aged horses before (Pre) and after supplementation (S) for 6 weeks (w) with either an antioxidant rich supplement (RespirAid) or placebo. Each group consists of 10 young horses and 10 aged horses. * = Significantly different compared to Pre (P < 0.0001).
Take Home Message
- An oral antioxidant and key trace mineral supplement (RespirAid) is able to increase and maintain plasma Vitamin C and Vitamin E concentrations when fed to both adult and aged horses.
- Deaton, C.M. et al. (2003) Pulmonary bioavailability of ascorbic acid in an ascorbate-synthesising species, the horse. Free Radic Res 37, 461-467
- Deaton, C.M. et al. (2004) Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction. Am J Vet Res 65, 80-87.
- Deaton, C.M. et al. (2005) Effect of acute airway inflammation on the pulmonary antioxidant status. Exp Lung Res 31, 653-670.
- Deaton, C.M. et al. (2002) Antioxidant supplementation and pulmonary function at rest and exercise. Equine Vet J Suppl, 58-65.
- Deaton, C.M. et al. (2004) Antioxidant supplementation in horses affected by recurrent airway obstruction. J Nutr 134, 2065S-2067S.
Research (affect on signs of respiratory disease):
QUESTION: Does an Oral Antioxidant Supplement Improve Owner-Reported Signs of Respiratory Disease?
- Vitamins C and E are important antioxidants in lung fluid and lung tissue1. Inflammation, caused by allergy (e.g. equine asthma) or infection, causes reduction in antioxidants allowing inflammation to persist2,3.
- Supplementation with oral antioxidants has been shown to reduce equine airway inflammation and associated clinical signs4,5.
Aim of Study
To investigate the effect of an oral antioxidant supplement (RespirAid, Science Supplements) on owner-reported signs of respiratory disease.
Prospective clinical case series = a group of horses selected for a particular reason (respiratory disease in this study) was followed over several months.
Horses were recruited with one or more of the following clinical signs of respiratory disease: cough, nasal discharge, increased respiratory rate, increased respiratory effort. Horses were fed an antioxidant, vitamin and trace element supplement (RespirAid, Science Supplements), at the recommended rate, for 10 days. Owners were asked to record the clinical score of several indicators of respiratory disease on a scale of 1-4 each day of the study (Table 1).
Table 1: Scale for owner scoring of clinical signs of respiratory disease
- Full data were obtained from 37/42 owners who agreed to participate (88% completion). There were no palatability issues.
- After 7 days of feeding RespirAid, median owner reported scores were significantly decreased from day 1 (Figure 1) for all indicators of respiratory disease.
Figure 1: Respiratory clinical scores before and following 7 days of RespirAid supplementation. * P<0.05; ** P<0.001; *** P<0.0001. C/T = clear/thin; T/Y = thick/yellow.
Take Home Message
- An oral antioxidant supplement (RespirAid) significantly reduced owner-reported respiratory signs within 7 days.
- Deaton et al. (2003) Pulmonary bioavailability of ascorbic acid in an ascorbate-synthesising species, the horse. Free Radic Res 37, 461-467
- Deaton et al. (2004) Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction. Am J Vet Res 65, 80-87.
- Deaton et al. (2005) Effect of acute airway inflammation on the pulmonary antioxidant status. Exp Lung Res 31, 653-670.
- Deaton et al. (2002) Antioxidant supplementation and pulmonary function at rest and exercise. Equine Vet J Suppl, 58-65.
- Deaton et al. (2004) Antioxidant supplementation in horses affected by recurrent airway obstruction. J Nutr 134, 2065S-2067S.