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GastroKind Powder

GastroKind Horse Gastric Support Supplement - 12.3lbs (5.6kg) Powder

Regular price $96.00

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GastroKind Horse Gastric Support Supplement

  • Winner of the International Innovation Awards 2017
  • Works rapidly to support a healthy stomach
  • Helps control stomach acidity
  • Developed with Vets & leading equine nutritionists
  • Contains 9 active ingredients
  • 12.3lb (5.6kg) tub gives approximately 1-month supply
Product Description:

What?

Winner of the International Innovation Awards 2017 GastroKind is a natural, unique formula developed by the leading veterinary scientists, nutritionists, and vets. The combination of ingredients promotes a healthy gastric environment, soothes the stomach walls, helps control acidity, and supports the natural anti-inflammatory processes in the gut.  Gastrokind can be fed to all horses during or following veterinary treatment to help encourage a healthy stomach environment and is a natural alternative to maintain a healthy gut. In clinical trials, GastroKind alone was associated with reduced ulcer scores and reduced behaviors associated with ulcers in both squamous and glandular ulcer diagnoses, and it was shown to be able to be effectively combined with omeprazole for horses with more severe ulcer scores.  See below for the science behind each active ingredient.

Why?

Many factors can contribute to gastric upset in horses, including type of diet, turnout access, feeding schedule, exercise routine, stress, and anxiety, among others. Symptoms of gastric issues can range from mild or even no symptoms to severe symptoms that disrupt the horse’s daily life and/or ability to be ridden. Some horses seem predisposed to gastric issues or ulcers, either due to breed or lifestyle, while others can develop issues seemingly without warning. Once gastric issues do develop, however, they tend to occur again – especially without treatment, change in management, and on-going support to prevent gastric irritation from returning. Due to the naturally acidic nature of the stomach – which is an integral part of digestion and preventing pathogen exposure – once irritation or ulcers develop, the acidity can cause more tissue damage and inflammation and prolong the issue.

When?

Horses with current gastric irritation or ulcers benefit from the supportive effects of GastroKind, either as a stand-alone or as a complement to veterinary level products. Further, any horse with known history of gastric irritation or ulcers or horses with high risk of ulcer development due to breed, lifestyle, or diet can benefit from GastroKind to provide consistent gastric support, with the goal of strengthening and protecting the gastric lining from damage.

The Science Behind the Active Ingredients

Ficus glomerata extract - Ficus glomerata or Cluster Fig is an evergreen tree and found all over India and Southeast Asia. Compounds in the fruit are extremely high in natural phenolics, flavonoids, phytosterols, and terpenoids and have high antioxidant capacity (Eshwarappa et al. 2015). Studies using an extract of Ficus glomerata have been shown to support the stomach lining, promote a healthy gastric environment, and help control acidity.

Saccharomyces cerevisiae - Yeast cells are high in a small protein called thioredoxin. Thioredoxin is found in all mammal cells and is a powerful antioxidant. Recent studies have shown that oral administration of thioredoxin support the gastric lining (mucosa)

MgOH - Magnesium hydroxide when used in combination with a pectin-lecithin formulation and Saccharomyces cerevisiae can support a healthy stomach.

Apple Pectin & Lecithin - Pectin-lecithin complexes have been studied in horses and support the total mucus concentration in gastric juice (Koller et al. 2010). Mucus helps protect the stomach lining from acid. A study in horses demonstrated that the combination of magnesium hydroxide, a pectin-lecithin complex, and Saccharomyces cerevisiae can support a healthy stomach.

Alfalfa - Alfalfa has natural buffering capacity, which means it can help protect the stomach walls. Studies have shown that alfalfa when used for this purpose has a greater effect compared with horses fed Bermuda grass hay. Alfalfa also has an important role in ensuring palatability, keep the active ingredients evenly distributed throughout the supplement so that settling does not occur, and keeping the moisture content of the supplement as low as possible - which ensures the active ingredients are persevered in shipping and storage.

Vitamin E – Vitamin E has been shown to aid the natural process of reducing stomach acidity, acid creation, and gastric acid volume (Cuevas et al, 2011; Huilgol et al. 2014). Vitamin E in high feeding rates also has significant anti-oxidative action, aiding the integrity of tissues.

Selenium - Selenium is an important co-factor for effective function of antioxidant enzymes and vitamins such as Vitamin E.

Vitamin C – Alongside Vitamin E, Vitamin C is the other major anti-oxidant. Vitamin C creation capacity also declines with age, and horses may not be able to produce enough Vitamin C during times of high need – like with tissue damage. Plus, Vitamin C has been shown to have a major role in supporting a healthy gastric environment. The antioxidant Vitamin C has also been shown to support the gastric lining whilst not interfering with the positive effects of omeprazole (Kohler et al. 2010), therefore ideal for use alongside veterinary treatment.

Instructions for Use & Feeding Guide:

Use the 150ml (94g) scoop provided.

Maintenance feeding rate or for horses following veterinary treatment or to promote a healthy stomach environment. 

Maintenance                                      Level 150ml (94g) scoops per day
Pony – approximately 550lbs             2
Horse – approximately 1100lbs          2
Large Horse – 1650lbs and over         3

For horses under veterinary treatment feed for 7-14 days at the therapeutic dose before moving to the maintenance feeding rate. 

Therapeutic                                        Level 150ml (94g) scoops per day
Pony – approximately 550lbs             3
Horse – approximately 1100lbs          4
Large Horse – 1650lbs and over         6

-Split daily dose between at least 2 meals. 

-If symptoms re-occur or increase in severity, then you should contact your veterinary surgeon.

-Monitor feeding other supplements containing selenium.

-Do not exceed the recommended intake

Ingredients & Composition: 

One of our core values is transparency. That’s why we list all the active ingredients per daily feeding rate so you know exactly what your horse is getting.

Active ingredients:
Per 1100lb maintenance dose 
(2 x 150ml) 188g GastroKind delivers: Fruit extracts 37.5g; Yeast 13.5g; Magnesium hydroxide 6.8g; Lecithin 6.8g; Apple pectin 3.4g; Vitamin C 3.4g; Vitamin E2000 IU; Selenium 0.7mg.

Composition:
Fruit extract, apple pectin, lecithin, yeast, magnesium hydroxide, Vitamin C, Vitamin E, selenium, alfalfa.

Analytical Constituents:
Protein 12.1%; Fiber 20.2%; Oils & Fats 2.2%; Ash 8.1%; Moisture <10%.

Additives (per kg):
Vitamin E (all rac-alpha tocopherol acetate, 3a700) 10,695 IU/kg; Selenium as Sodium selenite (E8-Selenium) 3.74 mg/kg.

Research (ulcer scores and symptoms):

QUESTION: Does a Gastric Ulcer Supplement Improve Clinical and Owner Reported Symptoms in Horses with Equine Gastric Ulcer Syndrome?

Background

  • Equine gastric ulcer syndrome (EGUS) is common in exercising horses and is further categorised as equine squamous gastric disease (ESGD) and/or equine glandular gastric disease (EGGD)1. Despite medication and changes in management, a proportion of horses suffer recurrence of EGUS.
  • A feed or supplement that could be used to aid the effective management of EGUS would be useful. GastroKind (Science Supplements) contains a combination of Vitamin E, Vitamin C, yeast powder, fruit pectin, lecithin, magnesium hydroxide and a novel (patented) fruit extract of Ficus glomerata.

Aim of Study

To investigate the effect of GastroKind on clinical and owner reported symptoms in horses with Equine Gastric Ulcer Syndrome

Study Design

  • Prospective clinical case series = a group of horses selected for a particular reason (EGUS in this study) was followed over several months following an intervention (treatment).

Study Outline

Eight horses diagnosed with EGUS grade 1- 41 by gastroscopy were enrolled in the trial. Five horses (62.5%) had ESGD whereas all 8 horses (100%) had EGGD (Table 1). Five horses with grade 1 or 2 ulceration were treated with GastroKind only. Three horses were given the recommended GastroKind dose (300ml twice daily) and two horses were given 100ml twice daily. Three horses with grade 3 or 4 ulceration were treated with oral omeprazole at standard doses (4mg/kg or 2mg/kg once daily) and GastroKind 300ml twice daily (Table 1). Horses underwent a second gastroscopic examination after approximately 4 weeks of treatment.

Study Results

  • All 8 horses with EGUS showed significant clinical improvement with either complete resolution of ulcers or reduction in ulcer score at second gastroscopy (Table 1).
  • Both ESGD and EGGD scores were significantly decreased at post-treatment gastroscopy (Figure 1). In the five cases treated with GastroKind alone, behavioral and gastroscopic improvements were observed, resulting in reduction of at least one grade of ulcer severity (Table 1).
Squamous and glandular ulcer score changes with treatment

Figure 1: Equine squamous gastric disease (ESGD) and equine glandular gastric disease (EGGD) scores pre- and post- treatment with Gastrokind oral supplement ± oral omeprazole. Ulcer grade was significantly lower for both ESGD and EGGD following treatment (P=0.014). * denotes outlier.

Description of ulcer changes and treatments, per horse

 Table 1: Treatment and gastroscopy findings of horses (n=8) with equine gastric ulcer syndrome (EGUS) treated with Gastrokind (GK) supplementation ± oral omeprazole. ESGD equine squamous gastric disease; EGGD equine glandular gastric disease.

Take Home Message

  • GastroKind supplementation resulted in improved behaviour and reduced gastroscopic ulcer scores in 5 horses with grade 1 and 2 gastric ulceration. Supplementation of Gastrokind in addition to oral omeprazole led to significant decrease in ulcer scores in 8/8 horses with EGGD ± ESGD.

References

  1. Sykes, B., Hewetson, M., Hepburn, R., Luthersson, N. and Tamzali, Y. (2015), European College of Equine Internal Medicine Consensus Statement—Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med, 29: 1288-1299
Research (ulcer scores - endurance horses): 

QUESTION: Does GastroKind Improve Gastroscopic Score of Equine Squamous Gastric Disease in Endurance Horses in Active Training?

Background

  • The prevalence of Equine Gastric Ulcer Syndrome (EGUS) in endurance horses is high with reports of 67-93% gastroscopic lesions in competition season1,2. The majority of lesions are reported to be equine squamous gastric disease (ESGD)1,2.
  • A supplement that could be used to aid the effective management of EGUS would be useful. GastroKind (Science Supplements) contains a combination of Vitamin E, Vitamin C, yeast powder, fruit pectin, lecithin, magnesium hydroxide and a novel (patented) fruit extract of Ficus glomerata.

Aim of Study

To investigate the efficiency of GastroKind for treating ESGD in endurance horses in active training.

Study Design

  • Prospective clinical case series = a group of horses selected for a particular reason (EGUS in this study) was followed over several months following an intervention (treatment).

Study Outline

Twenty-nine horses in active training at a professional endurance yard underwent gastroscopy for EGUS evaluation3. Horses with grade 3 or greater ESGD were allocated treatment with oral omeprazole 4 mg/kg once daily plus GastroKind (Science Supplements) 300 ml twice daily (OMP+GK; 4 horses). Horses with ESGD less than grade 3 were randomly allocated treatment with either GastroKind 300 ml twice daily (GK; 10 horses), oral sucralfate 12 mg/kg twice daily (SUC; 7 horses), or no treatment (NT; 8 horses). Horses were administered treatment for 6 weeks and then re-scoped and scored. One horse receiving NT retired and was therefore not re-scoped.

Study Results

  • All 29 horses initially gastroscoped had equine squamous gastric disease (ESGD); 4 horses had Grade 3 ESGD and 25 horses Grade 2 ESGD. No equine glandular gastric disease (EGGD) was observed.
  • All horses treated with OMP+GK and GK alone showed an improvement in ulcer score (Table 1). Approximately half the horses administered SUC or NT had an improved ulcer score at second gastroscopy (Table 1).
Change in median ulcer scores under various treatments

 Table 1: Median and range of change in gastroscopic equine squamous gastric disease (ESGD) scores in 28 endurance horses following treatment with omeprazole plus GastroKind (OMP+GK); GastroKind (GK), sucralfate (SUC), or no treatment (NT). 

  • There was no significant difference among pre-treatment ulcer scores of horses administered GK, SUC or NT indicating these horses all started with similar scores.
  • Ulcer scores were significantly reduced in the GK group following treatment but not for SUC or NT (Fig. 1, Table 1).
  • Post-treatment scores of the OMP+GK group were not significantly different from pre-treatment scores, however the low number of horses in this group limits further interpretation.
Graph of change in ulcer scores under various treatments

Figure 1: Median (and range) of gastroscopic ulcer scores in 28 endurance horses pre-treatment and 6 weeks post-treatment with omeprazole plus GastroKind (n=4; OMP+GK); GastroKind (n=10; GK), sucralfate (n=7; SUC), or no treatment (n=7; NT). *denotes a significant difference in pre- and post-treatment scores (P=0.004).

Take Home Message

  • GastroKind significantly decreased ulcer score in endurance horses with Grade 2 ESGD. Further work investigating the use of GastroKind for treatment of mild EGGD is warranted.

References

  1. Nieto JE, Snyder JR, Beldomenico P, Aleman M, Kerr JW, Spier SJ. (2004) Prevalence of gastric ulcers in endurance horses--a preliminary report. Vet J. 167(1):33-7.
  2. Tamzali, Y., Marguet, C., Priymenko, N. and Lyazrhi, F. (2011) Prevalence of gastric ulcer syndrome in high‐level endurance horses. Equine Veterinary Journal, 43: 141-144.
  3. Sykes B.W., Hewetson M., Hepburn R.J., Luthersson N., Tamzali Y. (2015) European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med. 29(5):1288-99.
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